Endogenous MMTV Proviruses Induce Susceptibility to Both Viral and Bacterial Pathogens
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Endogenous MMTV Proviruses Induce Susceptibility to Both Viral and Bacterial Pathogens
Most inbred mice carry germline proviruses of the retrovirus, mouse mammary tumor virus (MMTV) (called Mtvs), which have multiple replication defects. A BALB/c congenic mouse strain lacking all endogenous Mtvs (Mtv-null) was resistant to MMTV oral and intraperitoneal infection and tumorigenesis compared to wild-type BALB/c mice. Infection of Mtv-null mice with an MMTV-related retrovirus, type B...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2006
ISSN: 1553-7366,1553-7374
DOI: 10.1371/journal.ppat.0020128